From: Proceedings 10th World Congress of Cryosurgery
Use of vitrified organs and tissues for transplantation - theoretical and practical implications

November 1998
J Bodziony University of Saarland, Department of General Surgery, 66421 Homburg, Germany

My own results of implantation of macro-encapsulated vitrified islets of Langerhans shown better function of vitrified islets as compared with cryopreserved islets (1,2). Necrosis of the endocrine tissue was observed in both experimental groups, with the lowest degree in the vitrified islets. The results of function tests shown, that only the glucose-stimulated insulin release for vitrified islets was not significantly lower after cryopreservation in comparison with values before cryopreservation (100 9 and 99 9 ~tUhslet per hour respectively). The vitrification of other organs and tissues for transplantation will be discussed. The problems of high toxicity of vitrification solutions (VS) and the composition of some new VS will be presented.

1. J. Bodziony, P. Schmitt, G. Feifel: Transplantation Proceedings, 26, 1944, 833-834

2. J. Bodziony: Infusionsther Transfusionsmed 24, 1997, 363-392

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