Cryo-Forum

HYSTOLOGICAL EFFECTS OF CRYOSURGICAL-DAMAGE

September 1997
Franco Lugnani - Fabrizio Zanconati*
Urology Service, Sanatorio Triestino Hospital, Trieste, Italy
*Department of Anatomic Pathology, Ospedale Maggiore, Trieste University, Italy

The application of technologies and of the physiopathological principles of ice-therapy lesions described in the previous paragraphs, entails the damaging of both sound and pathological tissues of the prostate.

These lesions will modify in time, showing typical hystological pictures at the commonly used follow-up biopsies.

For a better understanding, I wish to produce here some examples of these hystological aspects. The most common pictures are: fibrosis and coagulative necrosis over the first few months, whereas around the sixth month, we may witness a prevalence of granulation tissue, jalinosis , and fibrosis . We may also have, and fairly frequently too, the thickening of the nerves Fig.7), squamous metaplasia of the re-epithelializing ducts, basal hyperplasia of the residual glandsí epithelia.